Case studies
Selected industrial and collaborative projects — the question, the modeling approach and the measured outcome.
Mixing & mass transfer
Mass transfer and mixing time in an aerated production vessel
Mixing time and kLa evaluated across operating points to locate the actual limiting mechanism instead of over-agitating the whole window.
Full case study on request — ask us for the details.
Reactor optimization
Impeller reconfiguration in a 160 m³ bioreactor
Alternating radial and axial impellers, evaluated experimentally and by CFD, improved mixing while cutting power demand at production scale.
Hydrodynamics
Vortex and free-surface behavior in stirred tanks
Free-surface simulation of the gas–liquid interface to assess vortex formation, surface aeration and their impact on process performance.
Full case study on request — ask us for the details.
Digital twin
A digital twin for continuous bioproduction
A collaborative project combining mechanistic models and process data into a digital twin supporting stable continuous operation.
Scale-up
Hybrid modeling for scale-consistent process transfer
Mechanistic reactor models combined with data-driven elements to predict scale-dependent behavior where correlations alone fall short.
Full case study on request — ask us for the details.
Scale-up
Morphology-consistent scale-up of filamentous cultivations
Scale-up based on the maximum energy dissipation rate, quantified by CFD, kept Streptomyces morphology comparable from shake flask to stirred-tank reactor.
Full case study on request — ask us for the details.Tell us where your process is losing performance and we will show you which of these approaches applies.
