SmartScaler

SmartScaler.
Simple scale-up solutions. Scientifically grounded.

Dedicated scale-up software for bioprocess teams. Combining ease of use with CFD-based engineering depth.

The challenge

Scale-up remains one of the highest-risk phases in bioprocess development.

  • Mixing effects change across scales
  • Oxygen transfer behaves differently
  • Power input does not scale linearly
  • Experimental validation at production scale is limited

Traditional approaches rely on heuristics or simplified correlations — often insufficient for complex systems.

CFD flow field of a Rushton turbine, top view
Flow field, Rushton turbine — © SimVantage

The solution

Smart scale-up. Without CFD complexity.

SmartScaler translates advanced CFD insights into a practical, easy-to-use software tool for process engineers.

It enables teams to

  • Compare scale-up strategies
  • Evaluate mixing and mass transfer limitations
  • Identify scale-dependent risks
  • Support engineering decisions before implementation

No CFD expertise required.

SmartScaler workflow: source reactor operating parameters feed a rapid response model of the cell microclimate, which produces the target reactor operating parameters
From source reactor to target reactor — the SmartScaler workflow.

How it works

Validated CFD studies, packaged for engineering workflows.

SmartScaler is built on validated CFD simulation studies and engineering-scale reactor analysis. Instead of requiring full CFD workflows, it provides:

  1. Pre-evaluated engineering relationshipsDerived from validated simulation studies rather than generic correlations.
  2. Structured scale comparisonLab, pilot and production scale side by side, under consistent assumptions.
  3. Clear visualization of critical parametersMixing, mass transfer and power input where they actually become limiting.
  4. Decision support tailored to industrial reactorsConfigurations and constraints that match real production equipment.

This ensures scientifically grounded scale-up without the complexity of CFD modeling.

SmartScaler in action — 51 seconds, no sound.

Industrial benefits

Built on science. Validated in industry.

With SmartScaler you will:

  • Reduce scale-up uncertainty
  • Avoid costly late-stage modifications
  • Improve reactor performance
  • Support regulatory documentation
  • Accelerate transfer from pilot to production

Free demo account

Try SmartScaler yourself — free.

Get a free demo account and explore SmartScaler with example reactors at your own pace. Cloud-based, nothing to install, no obligation.

Integration with SimVantage

Focused tool, complete platform.

SmartScaler complements the SimVantage simulation platform and expert consulting services. While SimVantage supports full modeling and process analysis, SmartScaler provides a focused environment for structured scale-up decisions.

Together, they enable reliable and systematic process development.

See the full platform

Discuss your process challenge with our experts.

Whether you are optimizing an existing reactor or planning industrial scale-up, we support your team with scientifically grounded, industrially validated modeling expertise.